Anti-CD276 Antibody [PD00-36]

HUABIO

Anti-CD276 Antibody [PD00-36]

2

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

PD00-36

1 mg/ml

Unconjugated

CD276

CD276 molecule

4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 antigen, B7 homolog 3, costimulatory molecule

Rabbit

IgG

CD276 antigen

The protein encoded by this gene belongs to the immunoglobulin superfamily. May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

-20°C,2°C to 8°C

41116161