Anti-CD32 Antibody [JM10-70]

HUABIO

Anti-CD32 Antibody [JM10-70]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

JM10-70

1 mg/ml

Unconjugated

FCGR2A

Fc gamma receptor IIa

CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-a, Fc fragment of IgG receptor IIa, Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc gamma receptor RIIa3, Immunoglobulin G Fc receptor II, fc-gamma-RIIa, fcRII-a, igG Fc receptor II-a

Rabbit

IgG

Low affinity immunoglobulin gamma Fc region receptor II-a

CD32 (also designated Fc gamma RII) is a low affinity receptor for the Fc fragment of aggregated IgG. CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells. IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells . CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C . These isoforms are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC . All isoforms are present on monocytes, placental trophoblasts and endothelial cells . In addition, the FcgRIIB forms are present on B lymphocytes, and the FcgRIIA and FcgRIIC forms are found on neutrophils.

Human

Human

-20°C,2°C to 8°C

41116161