Anti-CD32b [NOV0281], Human Fab fragment, His-Tagged, lambda

Absolute Antibody

Anti-CD32b [NOV0281], Human Fab fragment, His-Tagged, lambda

9

The specificity of the antibody for CD32b was determined by ELISA analysis. The antibody was able to bind to CD32b expressed on human B cells by flow cytometry analysis (binding affinity 5.4 nM). The binding of the antibody to the BJAB cell line was evaluated by flow cytometry (binding affinity 2.4 nM). The antibody bound to CHO cells expressing huCD32b in flow cytometry analysis. The human IgG1 format of the antibody was evaluated for its activity in a primary NK cell based antibody-dependent cell-mediated cytotoxicity (ADCC) assay. The antibody demonstrated concentration dependent specific cell lysis of both cancer cell lines evaluated (Jeko-1 and Karpas422 Cancer Cell) (US20170198040A1).

Flow Cytometry, ELISA, Other Application

Research Use Only

Monoclonal

NOV0281

FCGR2B

Fc gamma receptor IIb

CD32, CD32B, FCG2, FCGR2, FCGR2C, FcGRIIB, FcRII-c, FcgammaRIIb, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc fragment of IgG receptor IIb, Fc fragment of IgG, low affinity II, receptor for (CD32), Fc fragment of IgG, low affinity IIb, receptor (CD32), Fc fragment of IgG, low affinity IIb, receptor for (CD32), Fc gamma RIIb, Fc-gamma RII-c, Fc-gamma-RIIc, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-c, fc-gamma RII-b, fc-gamma-RIIb, fcRII-b, igG Fc receptor II-b

Human

Low affinity immunoglobulin gamma Fc region receptor II-b

Human

-20°C,2°C to 8°C

12352203