Anti-CD33 Antibody [PSH02-51]

HUABIO

Anti-CD33 Antibody [PSH02-51]

2

Flow Cytometry, ImmunoFluorescence, Western Blot

Research Use Only

Monoclonal

PSH02-51

1 mg/ml

Unconjugated

CD33

CD33 molecule

CD33rSiglec, SIGLEC-3, SIGLEC3, p67, myeloid cell surface antigen CD33, CD33 antigen (gp67), CD33 molecule transcript, gp67, sialic acid-binding Ig-like lectin 3

Rabbit

IgG

Myeloid cell surface antigen CD33

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.

-20°C,2°C to 8°C

41116161