Anti-CD35 Antibody [A4G1-R]

HUABIO

Anti-CD35 Antibody [A4G1-R]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

A4G1-R

1 mg/ml

Unconjugated

CR1

complement C3b/C4b receptor 1 (Knops blood group)

C3BR, C4BR, CD35, KN, complement receptor type 1, C3-binding protein, C3b/C4b receptor, CD35 antigen, Knops blood group antigen, complement component (3b/4b) receptor 1 (Knops blood group), complement receptor 1

Mouse

IgG1

Complement receptor type 1

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) family and is located in the cluster RCA region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

-20°C,2°C to 8°C

41116161