Anti-CD38 [OKT10]

Absolute Antibody

Anti-CD38 [OKT10]

9

This antibody recognizes and antigenic structure of 45,000 daltons type II transmembrane glycoprotein present on human precursor B cells and T cells, activated T cells, natural killer cells and some monocytes, myeloblasts and erythroblasts. It is also rep

This antibody reacts with various lymphoid cell populations and thymocytes. OKT10 along with other antibodies was used to describe the stages of intrathymic development of human thymocytes. It was reported that all the thymocytes intially bear the OKT10 marker. As the thymocytes are exported to peripheral T-cel compartment they lose the OKT10 marker, as OKT10 could not react with peripheral T-cells (PMID:6966400). OKT10 is reported to bind to leukaemias and normal marrow cells of the myeloid and B cell lineages (PMID:6169674). OKT10 was used to study final B cell maturation since the OKT10 antigen is expressed on mature lymphocytes and lymphoplasmacytic cells. OKT10 reactivity is inversely proportional to the presence of Ia-like antigen expression. Therefore, these two antigens can be employed as complementary opposite reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenstroem malignancy. (PMID:6813349). This antibody was used for determination of highly purified human NK cells by flow cytometry (PMID:6975321). This antibody was used for the identification of a CD38-like 78-Kilodalton soluble protein released from B Cell Lines derived from patients with X-linked Agammaglobulinemia (PMID:9637716)

Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

OKT10

CD38

CD38 molecule

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; CD38 antigen (p45); cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase

Mouse

IgG2b

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203