Anti-CD3D Antibody [JJ08-97]

HUABIO

Anti-CD3D Antibody [JJ08-97]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC,IP

Research Use Only

Monoclonal

JJ08-97

1 mg/ml

Unconjugated

CD3D

CD3 delta subunit of T-cell receptor complex

CD3-DELTA, CD3DELTA, IMD19, T3D, T-cell surface glycoprotein CD3 delta chain, CD3 antigen, delta subunit, CD3 delta, CD3d antigen, delta polypeptide (TiT3 complex), CD3d molecule, delta (CD3-TCR complex), OKT3, delta chain, T-cell receptor T3 delta chain

Rabbit

IgG

T-cell surface glycoprotein CD3 delta chain

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (gammaepsilon), a heterodimer of delta and epsilon chains (deltaepsilon) and a homodimer of two zeta chains (omegaomega) or a heterodimer of zeta and eta chains (omegah). The omega and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The gamma, epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the omega chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the omega chain ITAMs has been solved.

Human

Human

-20°C,2°C to 8°C

41116161