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anti-CD47 (human), mAb (ANC2F6) (R-PE)

anti-CD47 (human), mAb (ANC2F6) (R-PE)

Research Use Only
ANC-198-050
Ancell Corporation
ApplicationsFlow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
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Overview

  • Supplier
    Ancell Corporation
  • Product Name
    anti-CD47 (human), mAb (ANC2F6) (R-PE)
  • Delivery Days Customer
    7
  • Antibody Specificity
    Binds to an epitope within the extracellular Ig-like domain of human CD47.
  • Applications
    Flow Cytometry, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ANC2F6
  • Conjugate
    RPE
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer. - Monoclonal Antibody. Binds to an epitope within the extracellular Ig-like domain of human CD47. Isotype: Mouse IgG1kappa. Clone: ANC2F6. Applications: ELISA, FACS. Liquid. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2%BSA, 0.04% sodium azide. Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203