anti-CD47 (human), mAb (ANC2F6) (R-PE)
ANC-198-050
ApplicationsFlow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierAncell Corporation
- Product Nameanti-CD47 (human), mAb (ANC2F6) (R-PE)
- Delivery Days Customer7
- Antibody SpecificityBinds to an epitope within the extracellular Ig-like domain of human CD47.
- ApplicationsFlow Cytometry, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDANC2F6
- ConjugateRPE
- HostMouse
- IsotypeIgG1
- Scientific DescriptionHuman CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer. - Monoclonal Antibody. Binds to an epitope within the extracellular Ig-like domain of human CD47. Isotype: Mouse IgG1kappa. Clone: ANC2F6. Applications: ELISA, FACS. Liquid. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2%BSA, 0.04% sodium azide. Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203