Anti-CD48 [OX-45]

Absolute Antibody

Anti-CD48 [OX-45]

7

OX-45 binds specifically to CD48 on rat thymocytes, T and B cells and endothelium but not LFA.3. Directly competes with CD46 for binding the target epitope. CD48 is a CD2 ligand and is expressed on the surface of all hematopoietic cells and endothelium. M

Describes the use of OX-45 in blocking the primary mixed lymphocyte response (MLR)and the secondary response of T lymphocytes to the soluble antigen DNP-BGG. It also showed that OX-45 did not have any effect on the cytotoxic activity of specific (CTL) or non-specific (NK) killer cells or on proliferative responses stimulated by lectins or oxidative mitogenesis.

Flow Cytometry, Neutralisation/Blocking

blocking; FC

Research Use Only

Monoclonal

OX-45

Cd48

Cd48 molecule

BCM1 surface antigen; BLAST-1; CD48 antigen; MRC OX-45 surface antigen; signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF2

Mouse

IgG1

CD48 antigen

Rat

Rat

OX-45 was prepared by immunizing BALB/c mice with rat T blasts prepared by stimulating purified T helper (TH) cells with allogeneic irradiated rat spleen cells.

-20°C,2°C to 8°C

12352203