Anti-CD59 Antibody [JM10-71]

HUABIO

Anti-CD59 Antibody [JM10-71]

7

ImmunoPrecipitation, Western Blot

WB,IF-Cell,IF-Tissue,FC,IP

Research Use Only

Monoclonal

JM10-71

1 mg/ml

Unconjugated

CD59

CD59 molecule (CD59 blood group)

16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), CD59 blood group antigen, CD59 molecule, complement regulatory protein, Ly-6-like protein, MEM43 antigen, T cell-activating protein, human leukocyte antigen MIC11, lymphocytic antigen CD59/MEM43, membrane attack complex (MAC) inhibition factor, membrane attack complex inhibition factor, membrane inhibitor of reactive lysis, protectin, surface anitgen recognized by monoclonal antibody 16.3A5

Rabbit

IgG

CD59A glycoprotein

CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. It may also signal the cell to perform active measures such as endocytosis of the CD59-C9 complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161