Anti-CD68 Mouse mAb

PTM BIO

Anti-CD68 Mouse mAb

5

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF

Research Use Only

Monoclonal

JMMR-2659

Unconjugated

Mouse

IgG

Macrosialin

CD68 is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages. CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain. CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Stable for 12 months from date of receipt/reconstitution.

Human, Rat

Human, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203