Anti-CD71 Mouse mAb

PTM BIO

Anti-CD71 Mouse mAb

5

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF, FC

Research Use Only

Monoclonal

JMMR-2641

Unconjugated

Mouse

IgG

Transferrin receptor protein 1

CD71 (Transferrin receptor 1, TFRC) is a type II transmembrane receptor and carrier protein responsible for the uptake of cellular iron through receptor-mediated endocytosis. Neutral pH at the cell surface promotes binding of the iron-binding glycoprotein transferrin (Tf) to the CD71 receptor. The receptor-ligand complex enters the cell through receptor-mediated endocytosis and is internalized into an endosome. Relatively lower endosomal pH leads to a change in the local charge environment surrounding the iron-transferrin binding site and results in the release of iron. The receptor-ligand complex is recycled to the cell surface where transferrin dissociates from the CD71 receptor. Ubiquitously expressed transferrin receptor is continuously recycled and undergoes clathrin-mediated endocytosis regardless of ligand binding state.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203