Anti-CD79a [HM47]

Absolute Antibody

Anti-CD79a [HM47]

9

This antibody recognises CD79a which is involved in initiation of the signal transduction cascade activated by binding of antigen to the B-cell receptor. CD79a is used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissue sections.

IP: HM47 antibody was successfully used in immunoprecipitation of samples coming from NP-40 lysates of surface-labelled Daudi cells what confirmed participation of the mb-1 gene product in mIgM-associated heterodimer; subsequently a reprecipitation was performed as a confirmatory step (van Noesel et al., 1991). IHC: This antibody presented strong selective staining of B cell follicles in sections of lymphoid tissue (Mason et al., 1991). HM47 showed also high specificity in staining bone marrow samples with acute promyelocytic leukemia (APL) (stained 86% APL cases and only 10% of non-APL samples) (Bhargava et al., 2007).

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

HM47

CD79A

CD79a molecule

B-cell antigen receptor complex-associated protein alpha chain; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; IGA; ig-alpha; MB-1; MB-1 membrane glycoprotein; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein

Rabbit

IgG

B-cell antigen receptor complex-associated protein alpha chain

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Bovine, Chicken, Equine, Guinea Pig, Human, Mouse, Opossum, Porcine, Primate, Rabbit, Rat

-20°C,2°C to 8°C

12352203