Anti-CD80 Antibody [JF100-4]

HUABIO

Anti-CD80 Antibody [JF100-4]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

JF100-4

1 mg/ml

Unconjugated

CD80

CD80 molecule

B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, B-lymphocyte activation antigen B7, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CTLA-4 counter-receptor B7.1, activation B7-1 antigen, costimulatory factor CD80, costimulatory molecule variant IgV-CD80

Rabbit

IgG

T-lymphocyte activation antigen CD80

The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28 and CTLA-4 (CD152). CD80 can be found on the surface of various immune cells, including B-cells, monocytes, or T-cells, but most typically at antigen-presenting cells (APCs) such as dendritic cells. CD80 has a crucial role in modulatating T-cell immune function as a checkpoint protein at the immunological synapse. CD80 is the ligand for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. Another ligand of CD80 is programmed death-ligand 1 (PD-L1), expressed on the surface of T-cells, B-cells, DCs, and macrophages. This interaction is inhibiting and causes a reduction in T-cell activation as well as reduction of cytokine production. Its dissociation constant with CD80 is between the CD28 and CTLA-40 (Kd = 1.4 microM).

Human

Human

-20°C,2°C to 8°C

41116161