Anti-CD80 [B7-24]

Absolute Antibody

Anti-CD80 [B7-24]

7

This monoclonal antibody recognizes human CD80 expressed on human blood dendritic cells and on in vitro activated (but not resting) B cells and monocytes.

This mAb binds to a functionally important epitope of the B7 molecule. B7-24 is not able to inhibit T cell proliferation in primary mixed lymphocyte reactions where purified T cells are co-cultured with Epstein-Barr virus-transformed B cells. This antibody was used to study the cell surface expression of B7 antigen using flow cytometry. This antibody was also able to immunoprecipitate radioactive Iodine-labeled EBV-transformed B cells (PMID: 1280221). This antibody was used to examine the in situ expression of B7/BB1 by immunohistochemistry (PMID: 7682106).

Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry

FC; IP; IHC

Research Use Only

Monoclonal

B7-24

CD80

CD80 molecule

activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80

Human

IgG1

T-lymphocyte activation antigen CD80

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

The original antibody was generated by fusion with splenocytes from a mouse immunized with Sf9 insect cells expressing the human B7 molecule.

-20°C,2°C to 8°C

12352203