Anti-CD96 [6A6]

Absolute Antibody

Anti-CD96 [6A6]

9

This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain.

This antibody blocks murine CD96-CD155 interaction, and has been shown to bind to the first Ig domain of CD96 and compete with CD155 binding (Roman Aguilera et al, 2018). This antibody displays significant anti-metastatic activity in four experimental lung metastases models and one spontaneous tumour metastasis model (Roman Aguilera et al, 2018), with a potency greater than the anti-CD96 monoclonal antibodies 3.3 and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018).

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

6A6

Cd96

CD96 antigen

1700109I12Rik; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein; Tact; Tactile; T-cell surface protein tactile

Mouse

IgG2a

T-cell surface protein tactile

This chimeric mouse antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

12352203