Anti-Cdc25C Mouse mAb

PTM BIO

Anti-Cdc25C Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-2519

Unconjugated

Mouse

IgG

M-phase inducer phosphatase 3

Cdc25 is a protein phosphatase responsible for dePhosphorylatedrylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. cdc25C is constitutively Phosphorylatedrylated at Ser216 throughout interphase by c-TAK1, while Phosphorylatedrylation at this site is DNA damage-dependent at the G2/M checkpoint. When Phosphorylatedrylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 Phosphorylatedrylate cdc25C at Ser216 in response to DNA damage.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203