Anti-CDK1/Cdc2 Mouse mAb

PTM BIO

Anti-CDK1/Cdc2 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Research Use Only

Monoclonal

JMMR-1572

Unconjugated

Mouse

IgG

Cyclin-dependent kinase 1

CDC2, also named as CDK1, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily. CDC2 plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. It is a component of the kinase complex that Phosphorylatedrylates the repetitive C-terminus of RNA polymerase II. Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. CDK1 has 2 isoforms produced by alternative splicing with the molecular mass of 34 kDa and 27 kDa.

Stable for 12 months from date of receipt/reconstitution.

Human, Monkey

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203