Anti-CDK2 Rabbit mAb

PTM BIO

Anti-CDK2 Rabbit mAb

5

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF, FC

Research Use Only

Monoclonal

JRMR-10874-58

Unconjugated

Rabbit

IgG

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. Like p34cdc2, kinase activity is regulated by Phosphorylatedrylation state as well as association with a cyclin subunit and a CDK inhibitor. Inhibitory Phosphorylatedrylation occurs on Thr14 and Tyr15 (1). Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1 (2). Activation of CDK2 complexes requires dePhosphorylatedrylation of Thr14 and Tyr15 by cdc25 phosphatase and Phosphorylatedrylation of Thr160 (3), which is mediated by CAK, a complex of CDK7 and cyclin H (4). CDK2/cyclin E kinase activity is important for the G1 to S transition and Phosphorylatedrylation of the Rb protein. During S-phase, active CDK2/cyclin A complexes predominate and Phosphorylatedrylate E2F and the active CDK2 complex persists in the nucleus throughout G2 (5).

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203