Anti-CDK4 Mouse mAb

PTM BIO

Anti-CDK4 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

12884

Unconjugated

Mouse

IgG

Cyclin-dependent kinase 4

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that Phosphorylatedrylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylatedrylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. HypoPhosphorylatedrylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also Phosphorylatedrylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203