Anti-CEACAM1 Mouse mAb

PTM BIO

Anti-CEACAM1 Mouse mAb

5

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF

Antibody

Research Use Only

Monoclonal

13353

Unconjugated

Mouse

IgG

Carcinoembryonic antigen-related cell adhesion molecule 1

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is Phosphorylatedrylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dePhosphorylatedrylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and Phosphorylatedrylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dePhosphorylatedrylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203