Anti-CHFR Antibody

HUABIO

Anti-CHFR Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CHFR

checkpoint with forkhead and ring finger domains

RNF116, RNF196, E3 ubiquitin-protein ligase CHFR, RING finger protein 196, RING-type E3 ubiquitin transferase CHFR, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

Rabbit

IgG

E3 ubiquitin-protein ligase CHFR

E3 ubiquitin-protein ligase (CHFR) that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. CHFR is probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the Lys-48-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Marked reduction of CHFR expression was detected in primary tumors and decreased CHFR expression was linked to promoter hypermethylation. Restoration of CHFR expression by treatment with the microtubule stress agent nocodazole and the methyltransferase inhibitor 5-aza-2-deoxycytidine has been reported.

Human

Human

-20°C,2°C to 8°C

41116161