Anti-Chk1 Antibody [ST57-09]

HUABIO

Anti-Chk1 Antibody [ST57-09]

7

ImmunoFluorescence, Western Blot

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

ST57-09

1 mg/ml

Unconjugated

CHEK1

checkpoint kinase 1

CHK1, OZEMA21, serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint, S. pombe, homolog of, 1, Chk1-S, cell cycle checkpoint kinase

Rabbit

IgG

Serine/threonine-protein kinase Chk1

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161