Anti-Citrullinated collagen type II [ACC1]

Absolute Antibody

Anti-Citrullinated collagen type II [ACC1]

7

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). The binding specificity of mouse IgG2a version of this antibody towards citrullinated protein was determined through ELISA. This antibody was also used in the immunohistochemical staining of cartilage in paw samples obtained of arthritis induced mice. This antibody was also reported to induce and mediate arthritis in mice (PMID: 19204106). This antibody was also reported to cross react with noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. A study demonstrated the molecular mechanism on how ACC1 trigger arthritis (PMID: 28679953). This antibody was also used in the preparation of a cocktail for induction of rheumatoid arthritis in mice (PMID: 32448385).

ELISA, ImmunoHistoChemistry

Research Use Only

Monoclonal

ACC1

COL2A1

collagen type II alpha 1 chain

ACG2, ANFH, ANFH1, AOM, COL11A3, EDMMD, LCPD, OSCDP, PLSDT, SEDC, SEDSTN, SEMDSTWK, SMDALG, STL1, VPED, collagen alpha-1(II) chain, alpha-1 type II collagen, arthroophthalmopathy, progressive (Stickler syndrome), cartilage collagen, chondrocalcin, collagen II, alpha-1 polypeptide, collagen, type II, alpha 1

Rabbit

IgG

Collagen alpha-1(II) chain

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

-20°C,2°C to 8°C

41116161