Anti-Connexin 43 / GJA1 Rabbit mAb

PTM BIO

Anti-Connexin 43 / GJA1 Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JRMR-10487-13

Unconjugated

Rabbit

IgG

Gap junction alpha-1 protein

Connexin 43 (Cx43) is a member of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Src can interact with and Phosphorylatedrylate Cx43 to alter gap junction communication. Phosphorylatedrylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is Phosphorylatedrylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203