Anti-Cortactin Antibody [SC61-08]

HUABIO

Anti-Cortactin Antibody [SC61-08]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

SC61-08

1 mg/ml

Unconjugated

CTTN

cortactin

EMS1, src substrate cortactin, amplaxin, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate), epididymis secretory sperm binding protein, oncogene EMS1

Rabbit

IgG

Src substrate cortactin

Cortactin (also designated Ems-1) is a filamentous Actin (F-Actin) binding protein that has been shown to be a substrate for Src p60. Cortactin contains tandem 37 amino acid repeats at the amino-terminus and an SH3 domain at the carboxy-terminus. The tandem repeats appear to be necessary for F-Actin binding. Tyrosine phosphorylation of Cortactin by Src p60 results in diminished F-Actin binding to Cortactin and reduced F-Actin cross-linking activity. Cortactin has also been shown to be phosphorylated in response to FGF-1. Cortactin exhibits abundant expression in megakaryocytes and platelets, and it may play a role in the maturation of megakaryocytes.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161