Anti-CPS-500 [18.44]

Absolute Antibody

Anti-CPS-500 [18.44]

7

This antibody binds the CPS-500 antigen of sporozoites and merozoites of Cryptosporidium parvum. Cryptosporidium parvum is a coccidian parasite that infects intestinal epithelium and causes diarrheal disease in humans and other agriculturally important fo

This antibody reacts with both sporozoites and merozoites of C. parvum in an indirect immunofluorescence assay. This antibody is capable of neutralizing sporozoites and merozoites in a time dependent manner (PMID: 2193057; 2473130). This antibody can be used for the identification of sporozoites, merozoites and CPS-500 antigen of C. parvum using western blot. The identification of sporozoite-neutralizing antibody was done using ELISA (PMID: 20086143). This antibody in combination with PLA2 or LL37 was also used in the generation of a biocide fusion proteins to kill C. parvum sporozoites in vitro and in vivo (PMID: 20086143).

Electron Microscopy, ImmunoFluorescence, Western Blot, ELISA

WB; ELISA; IF; electron microscopy; therapeutic

Research Use Only

Monoclonal

18.44

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Parasite

Cryptosporidium parvum

The original antibody was generated by immunizing mice with whole cells of Cryptosporidium parvum.

-20°C,2°C to 8°C

12352203