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ProductsBack/Anti-CPSF73 Antibody [JE59-11]

Anti-CPSF73 Antibody [JE59-11]

HA720025
HUABIO
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCPSF3
100 ul
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Overview

  • Supplier
    HUABIO
  • Product Name
    Anti-CPSF73 Antibody [JE59-11]
  • Delivery Days Customer
    2
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    JE59-11
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID51692
  • Target name
    CPSF3
  • Target description
    cleavage and polyadenylation specific factor 3
  • Target synonyms
    CPSF-73, CPSF73, NEDMHS, NEDMHSN, cleavage and polyadenylation specificity factor subunit 3, cleavage and polyadenylation specific factor 3, 73kDa, mRNA 3'-end-processing endonuclease CPSF-73
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9QXK7
  • Protein Name
    Cleavage and polyadenylation specificity factor subunit 3
  • Scientific Description
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3-end-processing endonuclease. Also involved in the histone 3-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5 to 3 exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5-ACCCA-3 sequence in the histone pre-mRNA leaving a 3hydroxyl group on the upstream fragment containing the stem loop (SL) and 5 phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5 to 3 exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    41116161

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