Anti-CPV capsid [A3B10 (MAb 8)]

Absolute Antibody

Anti-CPV capsid [A3B10 (MAb 8)]

9

This antibody recognizes and binds the site B of the intact canine parvovirus capsid. It also cross reacts with feline panleukopenia virus. This antibody recognizes a conformational epitope on the viral capsid and does not bind denatured or heat treated v

This antibody is capable of neutralizing canine parvovirus and inhibit the hemagglutination of the homologous virus. This antibody can immunoprecipitate capsid protein (PMID: 6194613). Mab A3B10 is non-reactive on Western blots from gels of denatured CPV (PMID: 8259653). The mode of Fab binding suggests that the A3B10 neutralizing antibody cannot bind bivalently to the capsid across the two-fold axes (PMID: 7522904). The binding of A3B10 to intact capsid was tested using ELISA (PMID: 9770425). The scFv version of the antibody bound viral capsid with a 10-20 fold lower avidity as compared to the intact IgG (PMID: 10753725).

ImmunoPrecipitation, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

A3B10 (MAb 8)

Mouse

IgG2a

Virus

-20°C,2°C to 8°C

12352203