Anti-CPV capsid [A3B10 (MAb 8)]

Absolute Antibody

Anti-CPV capsid [A3B10 (MAb 8)]

7

This antibody is capable of neutralizing canine parvovirus and inhibit the hemagglutination of the homologous virus. This antibody can immunoprecipitate capsid protein (PMID: 6194613). Mab A3B10 is non-reactive on Western blots from gels of denatured CPV (PMID: 8259653). The mode of Fab binding suggests that the A3B10 neutralizing antibody cannot bind bivalently to the capsid across the two-fold axes (PMID: 7522904). The binding of A3B10 to intact capsid was tested using ELISA (PMID: 9770425). The scFv version of the antibody bound viral capsid with a 10-20 fold lower avidity as compared to the intact IgG (PMID: 10753725).

ImmunoPrecipitation, ELISA, Neutralisation/Blocking

NTRL; IP; ELISA

Research Use Only

Monoclonal

A3B10 (MAb 8)

Canine

IgG2

This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

Canine parvovirus, Feline panleukopenia virus

The original antibody was generated by immunizing mice with canine parvovirus virus.

-20°C,2°C to 8°C

12352203