Anti-CRACC/SLAMF7/CD319 Mouse mAb

PTM BIO

Anti-CRACC/SLAMF7/CD319 Mouse mAb

5

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry

ICC/IF, FC

Research Use Only

Monoclonal

13105

Unconjugated

Mouse

IgG

SLAM family member 7

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated. Besides, positively regulates NK cell functions by a mechanism dependent on Phosphorylatedrylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K.In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203