Anti-Crotonyl-Histone H4 (Lys12) Rabbit pAb
PTM-523
ApplicationsWestern Blot
Product group Antibodies
Overview
- SupplierPTM BIO
- Product NameAnti-Crotonyl-Histone H4 (Lys12) Rabbit pAb
- Delivery Days Customer5
- ApplicationsWestern Blot
- Applications SupplierWB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Protein IDP62805
- Protein NameHistone H4
- Scientific DescriptionHistones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. Crotonylation of histone H4 at Lys12 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
- Shelf life instructionStable for 12 months from date of receipt/reconstitution.
- Reactivity SupplierHuman, Mouse, Rat
- Reactivity Supplier NoteProtein A and immunogen affinity purified
- Storage InstructionStore at -20°C. Avoid freeze/thaw cycles.
- UNSPSC12352203