Anti-CXCL10 [2A]

Absolute Antibody

Anti-CXCL10 [2A]

7

The binding affinity of this antibody to rat CXCL10 was confirmed using ELISA. The IgG version of this antibody binds rat CXCL10 with a binding affinity of Kd= 150 pM. This antibody was capable of inhibiting migration of EL4 cells by CXCL-10 in a migration assay. Quantum dot nanocrystals labelled (Q-Dot-labeled) 2A was to study the movement and distribution of this antibody in collagen induced arthritis animal model using in vivo imaging technique. It was reported that the Q-Dot-labeled antibody was specifically accumulated in the joint area of the forefoot and lower foot, which are inflammation sites. The therapeutic effect of this antibody on arthritis was also studied in preclinical animal models of autoimmune arthritis. It was reported that there was a reduction in cell infiltration in a concentration dependent manner in the anti-CXCL-10-2A treated group, and the destruction of cartilage was also alleviated when compared to the IgG control treated control group. In the joints of the Anti-CXCL-10-2A injection group, the expression of inflammatory cytokines IL-17, TNF-alpha, IL-1beta, and IL-6 was low (KR1020130121601).

Functional Assay, ELISA

ELISA; functional assay; therapeutic

Research Use Only

C-X-C motif chemokine 10

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

-20°C,2°C to 8°C

12352203