Anti-CXCL10 [CC21R3P1_F1 (CC_F1)]

Absolute Antibody

Anti-CXCL10 [CC21R3P1_F1 (CC_F1)]

9

The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody towards human CXCL10 was determined using BIACORE and was found to be Kd= 9.2 nM. The neutralizing potential of the IgG version of this antibody on hCXCL10-induced calcium flux or cell chemotaxis was evaluated using the cell-based assays. This antibody was reported to inhibit the activity of both recombinant and native hCXCL10 in a dose-dependent manner. CXCL10 is able to oligomerize and bind to glycosaminoglycans (GAG) expressed at surface of cells such as endothelial cells. This antibody was capable of binding human CXCL10 immobilized on glycosaminoglycan (US7786268).

Functional Assay, ELISA

Research Use Only

Monoclonal

CC21R3P1_F1 (CC_F1)

CXCL10

C-X-C motif chemokine ligand 10

C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, gamma IP10, interferon-inducible cytokine IP-10, protein 10 from interferon (gamma)-induced cell line, small inducible cytokine subfamily B (Cys-X-Cys), member 10, small-inducible cytokine B10

Human

IgG1

C-X-C motif chemokine 10

Human

-20°C,2°C to 8°C

41116161