Anti-Cyclin B2 Antibody [SD2045]

HUABIO

Anti-Cyclin B2 Antibody [SD2045]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

SD2045

1 mg/ml

Unconjugated

CCNB2

cyclin B2

HsT17299, G2/mitotic-specific cyclin-B2

Rabbit

IgG

G2/mitotic-specific cyclin-B2

In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M-phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc 1). The Cdc/cyclin enzyme is subject to multiple levels of control of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/cyclin B enzyme and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex . Evidence has established that B-type cyclins not only act on M-phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B-type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161