Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Cyclin D1 RM241 at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Cyclin D1 RM241 at a 1:1000 dilution.
anti-Cyclin D1 (human), Rabbit Monoclonal (RM241)
REV-31-1122-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCCND1
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-Cyclin D1 (human), Rabbit Monoclonal (RM241)
- Delivery Days Customer5
- Antibody SpecificityThis antibody reacts to human Cyclin D1. This antibody may also react to bovine, mouse or rat Cyclin D1, as predicted by immunogen homology.
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM241
- FormulationLiquid
- Gene ID595
- Target nameCCND1
- Target descriptioncyclin D1
- Target synonymsB-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
- HostRabbit
- IsotypeIgG
- Protein IDP24385
- Protein NameG1/S-specific cyclin-D1
- Scientific DescriptionCyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. - Recombinant Antibody. This antibody reacts to human Cyclin D1. This antibody may also react to bovine, mouse or rat Cyclin D1, as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203