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anti-Cyclin D2 antibody

ARG54053
Arigo Biolaboratories
ApplicationsWestern Blot
Product group Antibodies
TargetCCND2
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-Cyclin D2 antibody
  • Delivery Days Customer
    23
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Concentration
    1.9 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID894
  • Target name
    CCND2
  • Target description
    cyclin D2
  • Target synonyms
    G1/S-specific cyclin-D2; KIAK0002; MPPH3
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition.Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.Also substrate for SMAD3,phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.Component of the ternary complex,cyclin D2/CDK4/CDKN1B,required for nuclear translocation and activity of the cyclin D-CDK4 complex by similarity.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203

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