anti-Cyclin D2 antibody

Arigo Biolaboratories

anti-Cyclin D2 antibody

23

Western Blot

Research Use Only

Monoclonal

1.9 mg/ml

Unconjugated

CCND2

cyclin D2

G1/S-specific cyclin-D2; KIAK0002; MPPH3

Mouse

IgG2b

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition.Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.Also substrate for SMAD3,phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.Component of the ternary complex,cyclin D2/CDK4/CDKN1B,required for nuclear translocation and activity of the cyclin D-CDK4 complex by similarity.

Human

-20°C

12352203