Anti-Cyclin D3 Antibody [SD20-43]

HUABIO

Anti-Cyclin D3 Antibody [SD20-43]

7

Western Blot

WB,IF-Cell,IF-Tissue,FC

Research Use Only

Monoclonal

SD20-43

1 mg/ml

Unconjugated

CCND3

cyclin D3

G1/S-specific cyclin-D3, D3-type cyclin

Rabbit

IgG

G1/S-specific cyclin-D3

The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl-1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161