anti-Cyclin H antibody

Arigo Biolaboratories

anti-Cyclin H antibody

23

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

1 mg/ml

Unconjugated

CCNH

cyclin H

CAK; CAK complex subunit; CDK-activating kinase complex subunit; CycH; cyclin-dependent kinase-activating kinase complex subunit; cyclin-H; MO15-associated protein; p34; p37

Mouse

IgG2b

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Human

-20°C

12352203