Anti-Cyclosporin A [R454511]

Absolute Antibody

Anti-Cyclosporin A [R454511]

9

R454511 binds to residues 1, 2, 3, 4, 5, 9 and 11 of CsA.

Mutagenesis of Cs-derivatives identified that R454511 binds to residues 1, 2, 3, 4, 5, 9 and 11 of CsA (Quesniaux et al, 1990). In ELISA experimenets, R454511 was found to bind to Cs conjugated with both Thr^2 (Thr^2-Cs-BSA) and Lys^8 (D-Lys^8-Cs-BSA) (Quesniaux et al, 1990). The crystal structure of R454511 in complex with CsA has been obtained to 2.65 A resolution (Altschuh et al, 1992).

ELISA, Other Application

Research Use Only

Monoclonal

R454511

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203