Anti-Cytokeratin 1 Antibody [SN72-08]

HUABIO

Anti-Cytokeratin 1 Antibody [SN72-08]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IF-Tissue

Research Use Only

Monoclonal

SN72-08

1 mg/ml

Unconjugated

KRT1

keratin 1

AEI2, CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK, keratin, type II cytoskeletal 1, 67 kDa cytokeratin, CK-1, cytokeratin 1, epidermolytic hyperkeratosis 1, hair alpha protein, keratin 1, type II, type-II keratin Kb1

Rabbit

IgG

Keratin, type II cytoskeletal 1

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161