Anti-Cytokeratin 15 Antibody [ST04-85]

HUABIO

Anti-Cytokeratin 15 Antibody [ST04-85]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IF-Tissue,FC

Research Use Only

Monoclonal

ST04-85

1 mg/ml

Unconjugated

KRT15

keratin 15

CK15, K15, K1CO, keratin, type I cytoskeletal 15, CK-15, cytokeratin 15, keratin 15, type I, keratin-15, basic, keratin-15, beta, type I cytoskeletal 15

Rabbit

IgG

Keratin, type I cytoskeletal 15

Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161