Anti-Cytokeratin 6 Antibody [SN71-07]

HUABIO

Anti-Cytokeratin 6 Antibody [SN71-07]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

SN71-07

1 mg/ml

Unconjugated

KRT6A

keratin 6A

CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3, keratin, type II cytoskeletal 6A, cytokeratin 6A, cytokeratin 6C, cytokeratin 6D, keratin 6A, , type II, keratin 6A, type II, keratin, epidermal type II, K6A, type-II keratin Kb6

Rabbit

IgG

Keratin, type II cytoskeletal 6A

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFalpha induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP beta transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

Human, Rat

Human,Rat

-20°C,2°C to 8°C

41116161