Anti-Daxx Antibody [SC54-06]

HUABIO

Anti-Daxx Antibody [SC54-06]

7

Flow Cytometry, ImmunoFluorescence, Western Blot

WB,IF-Cell,FC

Research Use Only

Monoclonal

SC54-06

1 mg/ml

Unconjugated

DAXX

death domain associated protein

BING2, DAP6, EAP1, SMIM40, death domain-associated protein 6, CENP-C binding protein, ETS1-associated protein 1, Fas-binding protein, death-associated protein 6, fas death domain-associated protein

Rabbit

IgG

Death domain-associated protein 6

Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2.

Human

Human

-20°C,2°C to 8°C

41116161