Anti-DDX58 Antibody [JE60-05]

HUABIO

Anti-DDX58 Antibody [JE60-05]

2

Western Blot

Research Use Only

Monoclonal

JE60-05

1 mg/ml

Unconjugated

RIGI

RNA sensor RIG-I

DDX58, RIG-I, RIG1, RLR-1, SGMRT2, antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, DExD/H-box helicase 58, RNA helicase RIG-I, probable ATP-dependent RNA helicase DDX58, retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein

Rabbit

IgG

Antiviral innate immune response receptor RIG-I

Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons.

-20°C,2°C to 8°C

41116161