Anti-demetalated SOD1 [D3-1], Human IgG1, kappa

Absolute Antibody

Anti-demetalated SOD1 [D3-1], Human IgG1, kappa

9

This antibody recognized SOD1A4V, SOD1H46R, SOD1G85R, SOD1G93A, and SOD1I112M, but not SOD1WT. Further the antibody did not recognize SOD1 in patients with sporadic ALS or other neurodegenerative diseases.

The original antibody was used for immunohistochemistry on spinal cord sections from patients with FALS. This antibody was used in vivo on transgenic rats with SOD1H46R mutation. The treatment improved phenotypes and extended the lifespan of the rats. This antibody was used for an ELISA on recombinant protein SOD1G93A (Minamiyama et al., 2023; PMID:36874245).

ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

D3-1

Human

IgG1

Human

-20°C,2°C to 8°C

12352203