anti-Dengue virus NS1 antibody [SQab1501]

Arigo Biolaboratories

anti-Dengue virus NS1 antibody [SQab1501]

23

Flow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

SQab1501

1 mg/ml

Unconjugated

POLY

polyprotein

DENV_gp1; polyprotein; polyprotein gene

Mouse

IgG2a

Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients blood samples (up to 50 microg/mL) or infected cell supernatants (various from ng/mL to microg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic.

Virus

-20°C

12352203