Anti-DFNA5 / GSDME Antibody

HUABIO

Anti-DFNA5 / GSDME Antibody

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

GSDME

gasdermin E

DFNA5, ICERE-1, gasdermin-E, DFNA5, deafness associated tumor suppressor, inversely correlated with estrogen receptor expression 1, non-syndromic hearing impairment protein 5, nonsyndromic hearing impairment protein

Rabbit

IgG

Gasdermin-E

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161