Anti-DGCR8 Antibody [ST04-79]

HUABIO

Anti-DGCR8 Antibody [ST04-79]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot

WB,IF-Cell,IF-Tissue,IP

Research Use Only

Monoclonal

ST04-79

1 mg/ml

Unconjugated

DGCR8

DGCR8 microprocessor complex subunit

C22orf12, DGCRK6, Gy1, pasha, microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, DiGeorge syndrome critical region gene 8

Rabbit

IgG

Microprocessor complex subunit DGCR8

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding.Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing.Involved in the silencing of embryonic stem cell self-renewal.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161