Anti-DIABLO Antibody [SC67-06]

HUABIO

Anti-DIABLO Antibody [SC67-06]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

SC67-06

1 mg/ml

Unconjugated

DIABLO

diablo IAP-binding mitochondrial protein

DFNA64, SMAC, diablo IAP-binding mitochondrial protein, diablo homolog, mitochondrial, diablo-like protein, direct IAP-binding protein with low pI, second mitochondria-derived activator of caspase, second mitochondria-derived activator of caspases

Rabbit

IgG

Diablo IAP-binding mitochondrial protein

The activation of caspases is a key regulatory step in apoptosis. Once cytochrome c is released from the mitochondria into the cytosol, it binds Apaf-1 to form an oligomeric cytochrome c/Apaf-1 complex, which induces caspase activation. Inhibitors of Apoptosis Proteins (IAPs), are a family of proteins that regulate the cytochrome c/Apaf-1 caspase activating pathway. Like cytochrome c, Smac (for second mitochondria-derived activator of caspase, also designated DIABLO in mouse for direct IAP binding protein with low PI) promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding IAPs and preventing them from inhibiting caspases. In healthy cells, Smac is a mitochondrial protein, but when cells undergo apoptosis, Smac is released into the cytosol.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161